Drug Discovery Books

AO (aldehyde oxidase) is a key enzyme in phase I drug metabolism, catalyzing a range of biotransformations such as oxidations, reductions, and hydrolyses. In this article, we highlight the challenges associated with AO-mediated metabolism, including unpredictable pharmacokinetics and interspecies variability. We also discuss strategic approaches to mitigate these risks early in the drug discovery process.

Medicinal chemists often face cardiotoxicity issues linked to inhibition of the hERG (human ether-à-go-go-related gene) channel. In a recent Coffee Chat, Drug Hunter CEO Dennis Hu, Director for Industry Research and Relations Dennis Koester, and Senior Scientific Editor Matt Hesse discussed ways to reduce hERG risks during lead optimization. They described approaches to reduce hERG affinity while retaining on-target potency and discussed case studies of drug programs that used these strategies to eliminate their hERG issues.

There are catalysis geniuses (looking at you, process chemists!) and then there are those of us just looking to put compounds in vials.  Here are the simplest conditions that'll get you what you want 90% of the time.  Beyond that you'll need to ask a guru like Nick White or Malcolm Huestis. Hope this table helps. Explore drughunter.co m for more.

STAT3 hyperactivity is implicated in over 70% of human cancers. Despite three decades of research spanning small molecules, nucleotides, and heterobifunctional degraders, no STAT3-targeted therapy has achieved regulatory approval. Of the 11 small molecule compounds that have entered clinical trials, only four remain in active investigation. This review explores the successes and setbacks in the ongoing pursuit of the first STAT3-targeted oncology drug. Read on for a deep dive into these efforts and the evolving landscape of small molecule STAT3 inhibitor drug discovery.

This page provides links to directories of CROs, CDMOs, drug discovery companies, drug discovery-focused investors, vendors for equipment, products, and software frequently used in drug discovery.