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  • Name :Epidermal growth factor receptor erbB1
    Target Synonym :Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog),Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian),Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog,Epidermal Growth Factor Receptor Tyrosine Kinase Domain,Cell Proliferation-Inducing Protein 61,Cell Growth Inhibiting Protein 40,EC 2.7.10.1,NISBD2,PIG61,MENA,EC:2.7.10.1,EC 2.7.10,Receptor tyrosine-protein kinase erbB-1,Proto-oncogene c-ErbB-1,Epidermal growth factor recep Number of Launched Drugs :31
    Number of Drugs in Clinical Trials :169
    Lastest Research Phase :Approved New Generation, Targeting Rare and Refractory Mutations of EGFR Small molecule Oncology/Cancer Non-small cell lung cancer Phase I Global

    Part of Bioactivity data

    EGR-HA2H8 -Cell-based assay
     EGF R CAR_T

    5e5 of anti-EGFR CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human EGF R Protein, His Tag (Cat. No. EGR-HA2H8) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). APC signal was used to evaluate the binding activity (QC tested).

    EGR-H522a -SPR
     EGF R SPR

    Immobilized Erbitux on CM5 Chip via anti-human Fc IgG, can bind Human EGF R, His Tag, low endotoxin (Cat.No. EGR-H522a) with an affinity constant of 0.492 nM as determined in SPR assay (Biacore T200) (Routinely tested).

    EGR-H522a -SPR
     EGF R SPR

    Human EGF R, His Tag, low endotoxin (Cat. No. EGR-H522a) captured on CM5 Chip via anti-His antibody can bind Human EGF, Mouse IgG2a Fc Tag (Cat. No. EGF-H525b) with an affinity constant of 2.76 nM as determined in SPR assay (Biacore T200) (Routinely tested).

    Protocol

    Synonym Name

    EGFR,ERBB,ERBB1,HER1,PIG61,mENA

    Background

    The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

    Clinical and Translational Updates

    Public Drug Information

    Astrazeneca Pharmaceutical Co Ltd 2015-11-13 Uterine Neoplasms; Urinary Bladder Neoplasms; Multiple Myeloma; Prostatic Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Meningeal Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Brain metastases; Adenocarcinoma of Lung; Endometrial Neoplasms; Thyroid Neoplasms; Carcinoma, Squamous Cell; Lymphoma; Glioma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Adenocarcinoma; Melanoma; Esophageal Neoplasms; Liver Neoplasms; Head and Neck Neoplasms; Neoplasm, Residual; Ovarian Neoplasms; Hematologic Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Neoplasms; Glioblastoma; Colonic Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Skin Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms Details PX-070101 PX-070101 Approved Praxis Pharmaceuticals Colombia Diabetic Foot Praxis Pharmaceuticals 2015-07-01 Diabetic Foot Details Cetuximab sarotalocan RM-1929; ASP-1929 Approved Aspyrian Therapeutics Akalux Japan Head and Neck Neoplasms Rakuten Medical Inc 2020-09-25 Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck Details Cetuximab IMC-C255; BMS-564717; EMD-271786; C-255; GT-MAB-5.2; ch-225; LY-2939777; NSC-714692 Approved Bristol-Myers Squibb Company, Eli Lilly And Company, Merck Serono 爱必妥, Erbitux United States Colorectal Neoplasms Imclone Gmbh 2004-02-12 Carcinoma, Squamous Cell; Oropharyngeal Neoplasms; Neuralgia; Colorectal Neoplasms; Peritoneal Neoplasms; Glioma; Lung Neoplasms; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Laryngeal Neoplasms; Nasopharyngeal Carcinoma; Adenocarcinoma, Mucinous; Fallopian Tube Neoplasms; Complex Regional Pain Syndromes; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis; Gastrointestinal Neoplasms; Precancerous Conditions; Glioblastoma; Liver Neoplasms; Head and Neck Neoplasms; Solid tumours; Ovarian Neoplasms; Pain; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Neoplastic Cells, Circulating; Neoplasms; Small Cell Lung Carcinoma; Hypopharyngeal Neoplasms; Neoplasms, Squamous Cell; Colonic Neoplasms; Chordoma; Carcinoma, Adenoid Cystic; Sarcoma Details Afatinib Dimaleate BIBW-2992-MA2; BIBW-2992 Approved C.H. Boehringer Sohn Ag & Co. Kg Gilotrif, Giotrif, Tovok, 吉泰瑞, Tomtovok United States Carcinoma, Non-Small-Cell Lung C.H. Boehringer Sohn Ag & Co. Kg 2013-07-12 Esophageal Squamous Cell Carcinoma; Urethral Neoplasms; Brain Neoplasms; Prostatic Neoplasms; Ureteral Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Squamous Cell; Breast Neoplasms; Gallbladder Neoplasms; Uterine Neoplasms; Lymphoma; Glioma; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Neoplasm Metastasis; Small Cell Lung Carcinoma; Head and Neck Neoplasms; Solid tumours; Hematologic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Renal Insufficiency; Neoplasms; Rhabdomyosarcoma; Neuroectodermal Tumors; Glioblastoma; Neoplasms, Squamous Cell; Urinary Bladder Neoplasms; Chordoma; Liver Diseases; Multiple Myeloma Details Epidermal growth factor biosimilar (RAS Lifesciences) Approved Ras Lifesciences India Ras Lifesciences 2012-10-01 Details Recombinant epidermal growth factor gel (Pavay Gene Pharmaceutical) Approved Guilin Huanuowei Gene Pharmaceutical Co Ltd Mainland China Skin Ulcer; Burns Guilin Huanuowei Gene Pharmaceutical Co Ltd 2002-12-23 Skin Ulcer; Burns Details Nimotuzumab OSAG-10; KI-0502; KI-0501; DE-766; h-R3; OSAG-101; TheraCIMh-R3; YMB-1000 Approved Center Of Molecular Immunology, Cimym Biosciences BIOMAb-EGFR, TheraCIM, 泰欣生, CIMAher, Theraloc India Head and Neck Neoplasms; Nasopharyngeal Neoplasms 2006-07-21 Pancreatic neuroendocrine tumors (pNET); Esophageal Diseases; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Glioma; Esophageal Squamous Cell Carcinoma; Colorectal Neoplasms; Nasopharyngeal Carcinoma; Pancreatic Neoplasms; Head and Neck Neoplasms; Nasopharyngeal Diseases; Neoplasms; Nasopharyngeal Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Solid tumours Details Recombinant epidermal growth factor (Center for Genetic Engineering and Biotechnology/Praxis Pharmaceuticals) Approved Praxis Pharmaceuticals, Center For Genetic Engineering And Biotechnology Heberprot-P Diabetic Foot 2007-09-01 Diabetic Foot Details Erlotinib Hydrochloride CP-358774-01; RO-0508231; NSC-718781; CP-358774; RG-1415; OSI-774; R-1415 Approved Genentech Inc Tarceva, 特罗凯 Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung Roche Registration Gmbh 2004-11-18 Head and Neck Neoplasms; Kidney Neoplasms; Cystadenocarcinoma; Solid tumours; Ovarian Neoplasms; Liver Neoplasms; HIV Infections; Adenomatous Polyposis Coli; Neoplasm Recurrence, Local; Ependymoma; Brenner Tumor; Rhabdomyosarcoma; Medulloblastoma; Leukemia, Promyelocytic, Acute; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Cystadenocarcinoma, Mucinous; Anus Neoplasms; Esophageal Neoplasms; Esthesioneuroblastoma, Olfactory; Granuloma, Lethal Midline; Carcinoma, Basal Cell; Rectal Neoplasms; Cystadenocarcinoma, Serous; Polycythemia Vera; Anaplasia; Stomach Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Salivary Gland Neoplasms; Pancreatic Neoplasms; Skin Neoplasms; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Acute; Colonic Neoplasms; Carcinoma, Ovarian Epithelial; Glioblastoma; Nasopharyngeal Neoplasms; Adenocarcinoma of Lung; Fibrosis; Carcinoma, Verrucous; Liver Cirrhosis; Leukemia, Myelomonocytic, Chronic; Mesothelioma; Urinary Bladder Neoplasms; P Details Gefitinib ZD-1839 Approved Astrazeneca Plc Iressa, 易瑞沙 Japan Carcinoma, Non-Small-Cell Lung Astrazeneca Pharmaceutical Co Ltd 2002-07-05 Adenocarcinoma, Bronchiolo-Alveolar; Lip Neoplasms; Leukemia, Myeloid, Acute; Glioma; Carcinoma, Squamous Cell; Brain metastases; Lung Neoplasms; Carcinoma, Mucoepidermoid; Astrocytoma; Gliosarcoma; Paranasal Sinus Neoplasms; Colorectal Neoplasms; Gastrinoma; Carcinoma, Adenosquamous; Nasopharyngeal Carcinoma; Medullary thyroid cancer (MTC); Urethral Neoplasms; Brain Neoplasms; Breast Neoplasms; Neoplasms, Germ Cell and Embryonal; Uterine Cervical Neoplasms; Tongue Neoplasms; Thyroid Cancer, Papillary; Somatostatinoma; Carcinoma, Hepatocellular; Breast Neoplasms, Male; Gastrointestinal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Prostatic Neoplasms; Adenocarcinoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Thyroid Neoplasms; Neoplasms, Neuroepithelial; Lymphoma; Mouth Neoplasms; Laryngeal Neoplasms; Carcinoma, Renal Cell; Carcinoid Tumor; Parathyroid Neoplasms; Esthesioneuroblastoma, Olfactory; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Basal Cell; Granuloma, Lethal Midlin Details Brigatinib AP-26113 Approved Ariad Pharmaceuticals Inc Alunbrig, ALUNBRIG United States Carcinoma, Non-Small-Cell Lung Takeda Pharmaceuticals U.S.A. Inc 2017-04-28 Solid tumours; Ependymoma; Carcinoma; Neoplasms; Neurofibromatosis 2; Small Cell Lung Carcinoma; Myofibroma; Lymphoma, Large-Cell, Anaplastic; Brain metastases; Lung Neoplasms; Granuloma, Plasma Cell; Carcinoma, Non-Small-Cell Lung; Sarcoma, Kaposi; Neurilemmoma; Meningioma; Neuroma, Acoustic Details Recombinant Human Epidermal Growth Factor Derivative (Shenzhen Wastin Genetech) Approved Shenzhen Watsin Genetech Ltd 金因肽, GeneTime Mainland China Wounds and Injuries Shenzhen Watsin Genetech Ltd 2001-01-01 Wounds and Injuries Details Nepidermin DWP-401 Approved Daewoong Pharmaceutical Co Ltd Easyef South Korea Alopecia; Diabetic Foot Daewoong Pharmaceutical Co Ltd 2001-01-01 Diabetic Foot; Alopecia; Dry Eye Syndromes Details Icotinib Hydrochloride BPI-2009H; BPI-2009C Approved Betta Pharmaceuticals Co Ltd 凯美纳, Conmana Mainland China Carcinoma, Non-Small-Cell Lung Betta Pharmaceuticals Co Ltd 2011-06-07 Nasopharyngeal Carcinoma; Neuroma, Acoustic; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Squamous Cell; Lung Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma, Adenosquamous; Solid tumours; Psoriasis; Adenocarcinoma of Lung; Neurofibromatosis 2; Small Cell Lung Carcinoma; Bronchial Neoplasms; Stomach Neoplasms; Esophageal Neoplasms Details Recombinant human EGF conjugated vaccine Approved Biotech Pharmaceuticals Co Ltd YH-25448; JNJ-73841937; JNJ-1937; GNS-1480 Approved Oscotec Inc, Janssen Biotech Inc, Yuhan Corp Leclaza South Korea Carcinoma, Non-Small-Cell Lung Yuhan Corp 2021-01-18 Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung Details Recombinant epidermal growth factor biosimilar (Elea) r-hu-EGF Approved Argentina Diabetic Foot; Burns 2015-01-01 Diabetic Foot; Burns Details Recombinant Human Epidermal Growth Factor Derivative Eye Drops (Shenzhen Wastin Genetech) Approved Shenzhen Watsin Genetech Ltd 金因舒, GeneSoft Mainland China Corneal Diseases Shenzhen Watsin Genetech Ltd 2004-01-21 Corneal Diseases Details Necitumumab LY-3012211; IMC-11F8 Approved Eli Lilly And Company Portrazza United States Carcinoma, Non-Small-Cell Lung Eli Lilly And Co (Ireland) Ltd 2015-11-24 Solid tumours; Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details Sunvozertinib DZD-9008 Approved Dizal (Jiangsu) Pharmaceutical Co Ltd Mainland China Carcinoma, Non-Small-Cell Lung Dizal (Jiangsu) Pharmaceutical Co Ltd 2023-08-22 Lymphoma, B-Cell; Hepatic Insufficiency; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung Details Panitumumab ABX-0303; E7.6.3; AMG-954; ABX-EGF; ABX-10221 Approved Amgen Inc Vectibix United States Colorectal Neoplasms Amgen Inc 2006-09-27 Small Cell Lung Carcinoma; Exanthema; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Neoplasm Metastasis; Glioma; Carcinoma, Squamous Cell; Lung Neoplasms; Adenoma, Pleomorphic; Colorectal Neoplasms; Brain Neoplasms; Prostatic Neoplasms; Colonic Neoplasms; Head and Neck Neoplasms; Pancreatic Neoplasms; Neoplasms; Malignant Carcinoid Syndrome; Salivary Gland Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Carcinoma; Kidney Neoplasms; Solid tumours Details Neratinib Maleate CAN-030; PB-272; HKI-272; PF-0528767; WAY-179272 Approved Pfizer Inc Nerlynx, 贺俪安 United States Breast Neoplasms Puma Biotechnology Inc 2017-07-17 Solid tumours; Esophageal Neoplasms; Neoplasms; Breast Neoplasms; Hepatic Insufficiency; Colorectal Neoplasms; Lung Neoplasms; Brain metastases; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung Details Cetuximab biosimilar (CinnaGen) Approved Cinnagen Colorectal Neoplasms Cinnagen 2017-01-01 Colorectal Neoplasms Details Lapatinib Ditosylate Hydrate GW-572016; GW-572016F; GW-2016 Approved Glaxosmithkline Plc, Novartis Pharma Ag Tykerb, Tyverb, 泰立沙, Tykerb/Tyverb United States Breast Neoplasms Novartis Pharma Ag 2007-03-13 Laryngeal Neoplasms; Prostatic Neoplasms; Gliosarcoma; Colorectal Neoplasms; Astrocytoma; Bile Duct Neoplasms; Carcinoma, Acinar Cell; Carcinoma, Mucoepidermoid; Endometrial Neoplasms; Neoplasms, Gonadal Tissue; Lung Neoplasms; Carcinoma, Squamous Cell; Glioma; Brain Neoplasms; Gallbladder Neoplasms; Brain metastases; Lymphoma; Uterine Cervical Neoplasms; Adenocarcinoma; Melanoma; Tongue Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Neuroma, Acoustic; Carcinoma, Hepatocellular; Neoplasm Metastasis; Glioblastoma; Ovarian Neoplasms; Ependymoma; Head and Neck Neoplasms; Liver Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma; Abdominal Neoplasms; Salivary Gland Neoplasms; Medulloblastoma; Carcinoma, Verrucous; Neoplasms; Neurofibromatosis 2; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Central Nervous System Neoplasms; Urinary Bladder Neoplasms; Oligodendroglioma; Ca Details Recombinant epidermal growth factor (Shanghai Haohai ) Approved Shanghai Haohai Biological Technology Co Ltd Mainland China Burns Shanghai Haohai Biological Technology Co Ltd 2001-01-01 Burns Details Amivantamab CNTO-4424; JNJ-61186372; CNTO4424; JNJ-372; JNJ-6372 Approved Genmab A/S, Johnson & Johnson Innovative Medicine RYBREVANT United States Carcinoma, Non-Small-Cell Lung Janssen Biotech Inc 2021-05-21 Esophageal Neoplasms; Stomach Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Adenoid Cystic; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Hepatocellular Details Recombinant epidermal growth factor drop (Pavay Gene Pharmaceutical) Approved Guilin Huanuowei Gene Pharmaceutical Co Ltd Mainland China Corneal Diseases Guilin Huanuowei Gene Pharmaceutical Co Ltd 2002-04-12 Corneal Diseases; Xerophthalmia Details Pyrotinib Maleate HTI-1001; SHR-1258; BLTN Approved Jiangsu Hengrui Medicine Co Ltd Mainland China Breast Neoplasms Jiangsu Hengrui Medicine Co Ltd 2018-08-12 Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Adenocarcinoma of Lung; Neoplasms; Breast Neoplasms; Bile Duct Neoplasms; Lung Neoplasms; Metastatic breast cancer; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung Details Dacomitinib PF-00299804-03; PF-00299804-3; PF-00299804; PF-299804; PF-299; PF-804 Approved Pfizer Inc Vizimpro United States Carcinoma, Non-Small-Cell Lung Pfizer Inc 2018-09-27 Brain Neoplasms; Adenocarcinoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Penile Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Mouth Neoplasms; Lung Neoplasms; Colorectal Neoplasms; Solid tumours; Liver Diseases; Carcinoma, Large Cell; Glioblastoma; Neoplasms; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Head and Neck Neoplasms Details Mouse epidermal growth factor (Hangzhou Tianmushan Pharmaceutical) Approved Hangzhou Tianmushan Pharmaceutical Enterprise Co Ltd Phase 3 Clinical Beijing Avistone Pharmaceuticals Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details YK-029A YK-029A; YK-209A; YK-209-A; YK-029-A Phase 3 Clinical Hainan Yuekang Biomedicine Co Ltd Drug-Related Side Effects and Adverse Reactions; Carcinoma, Non-Small-Cell Lung Details Olafertinib CK-101; RX-518; CS-2481; EGFR-IN-3 Phase 3 Clinical Suzhou Neupharma Co Ltd Lung Diseases; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details Mefatinib Phase 3 Clinical Suzhou Maitai Bio-Technology Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details Cetuximab biosimilar (AlphaMab) KN-005 Phase 3 Clinical Suzhou Alphamab Co Ltd Head and Neck Neoplasms; Anus Neoplasms; Urinary Bladder Neoplasms; Colorectal Neoplasms Details MRG-003 MRG-003; MRG003 Phase 3 Clinical Shanghai Miracogen Inc Head and Neck Neoplasms; Solid tumours; Biliary Tract Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Esophageal Neoplasms; Nasopharyngeal Carcinoma; Bile Duct Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details HA121-28 HA121-28; SYHA121-28 Phase 3 Clinical CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co Ltd Biliary Tract Neoplasms; Solid tumours; Esophageal Neoplasms; Neoplasms; Medullary thyroid cancer (MTC); Bile Duct Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details Nimotuzumab biosimilar (El Kendi Pharmaceuticals Manufacturing) Phase 3 Clinical El Kendi Pharmaceuticals Uterine Cervical Neoplasms Details Cetuximab biosimilar (AMPO Biotechnology) Phase 3 Clinical Ampo Biotechnology Inc Colorectal Neoplasms Details Cetuximab biosimilar (R-Pharm) RPH-002 Phase 3 Clinical R-Pharm Head and Neck Neoplasms; Pancreatic Neoplasms Details QL1203 QL-1203 Phase 3 Clinical Qilu Pharmaceutical Co Ltd Colorectal Neoplasms Details BEBT-109 BEBT-109 Phase 3 Clinical Guangzhou BeBetter Medicine Technology Co Carcinoma, Non-Small-Cell Lung Details Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details Izalontamab SI-B001; SI-1X6.4 Phase 3 Clinical Sichuan Baili Pharmaceutical Co Ltd Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Neoplasms, Glandular and Epithelial; Triple Negative Breast Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details SKLB-1028 SKLB-1028 Phase 3 Clinical Sichuan University, CSPC Pharmaceutical Group Ltd Solid tumours; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute Details Varlitinib Ditosylate SPS-4370; ASLAN-001; ARRY-334543; ARRY-543; QBT-01 Phase 3 Clinical Array Biopharma Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Bile Duct Neoplasms Details Becotatug JMT-101 Phase 3 Clinical Shanghai Jmt-Bio Inc Solid tumours; Rectal Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details Izalontamab brengitecan BL-B01D1 Phase 3 Clinical Sichuan Baili Pharmaceutical Co Ltd, SystImmune Nasopharyngeal Carcinoma; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Colorectal Neoplasms; Urologic Neoplasms; Breast Neoplasms; Solid tumours; Digestive System Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Carcinoma, Transitional Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms, Fibroepithelial Details Nimotuzumab biosimilar (IBC Generium) Phase 3 Clinical International Biotechnology Center Generium Llc Head and Neck Neoplasms Details Depatuxizumab mafodotin ABT-414; ABT-414/806 Phase 3 Clinical Abbvie Inc Glioblastoma; Gliosarcoma; Carcinoma, Squamous Cell; Glioma Details EG-007 EG-007 Phase 3 Clinical Evergreen Therapeutics Inc Endometrial Neoplasms Details Larotinib Mesylate Z-650 Phase 3 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Pancreatic Neoplasms; Esophageal Squamous Cell Carcinoma Details Ametumumab SY-101 Phase 2 Clinical Institute of Bioengineering Academy of Military Medical Sciences Chinese People's Liberation Army, Shanghai Serum Bio-Technology Co Ltd Solid tumours; Colorectal Neoplasms Details BB-401 BB-401 Phase 2 Clinical Benitec Biopharma Ltd Squamous Cell Carcinoma of Head and Neck Details Sutetinib Maleate Phase 2 Clinical Jiangsu Maidu Pharmaceutical R & D Co Ltd, Jiangsu Suzhong Pharma Group Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details Petosemtamab MCLA-158 Phase 2 Clinical Merus Nv Solid tumours; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Neoplasm Metastasis Details GC-1118A GC-1118; GC-1118A Phase 2 Clinical GC Biopharma Corp Solid tumours; Stomach Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis Details Durvalumab/Gefitinib Phase 2 Clinical Medimmune Carcinoma, Non-Small-Cell Lung Details Pamvatamig MCLA-129 Phase 2 Clinical Merus Nv Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details JNJ-26483327 JNJ-26483327; MTKi-327; BGB-102 Phase 2 Clinical Johnson & Johnson Solid tumours; Neoplasms; Macular Degeneration Details HER-1 vaccine (Center of Molecular Immunology) HER1-ECD; HER1-VSSP; HER-1-ECD-VSSP Phase 2 Clinical Center Of Molecular Immunology Neoplasms Details AFM-24 AFM-24 Phase 2 Clinical Affimed Solid tumours Details C225-ILS-DOX C225-ILs-dox Phase 2 Clinical Universitaetsspitals Basel Breast Neoplasms Details Nazartinib EGF-816; EGFRmut-TKI EGF816 Phase 2 Clinical Novartis Pharma Ag Bronchial Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details Sapitinib AZD-8931 Phase 2 Clinical Astrazeneca Plc Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details Tesevatinib XL-647; KD-020; KD-019; EXEL-7647 Phase 2 Clinical Exelixis Inc Glioblastoma; Neoplasms; Brain Neoplasms; Breast Neoplasms; Polycystic Kidney, Autosomal Dominant; Brain metastases; Polycystic Kidney, Autosomal Recessive; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details Futuximab/Modotuximab Sym-004; S95026; S-95026; 992-and-1024 Phase 2 Clinical Symphogen A/S Solid tumours; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Glioma Details DBPR-112 ABT-101; DBPR-112 Phase 2 Clinical National Health Research Institutes Solid tumours; Head and Neck Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details Panitumumab-IRDye800CW (Stanford University) Phase 2 Clinical Stanford University Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Brain Neoplasms Details AMX-3009 Maleate AMX-3009; AMX3009马来酸 Phase 2 Clinical Anrun Medicine Technology (Suzhou) Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details Allitinib Tosylate AST-6; ALS-1306; AST-1306 Phase 2 Clinical Shanghai Allist Pharmaceutical Technology Co Ltd Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details Demupitamab SCT-200 Phase 2 Clinical SinoCelltech Ltd Ovarian Neoplasms; Biliary Tract Neoplasms; Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Carcinoma; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Gallbladder Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details Cetuximab-IRDye800CW (University Medical Center Groningen) Phase 2 Clinical Umcg The University Medical Center Groningen Rectal Neoplasms; Small Cell Lung Carcinoma; Penile Neoplasms; Lung Neoplasms Details Selatinib Ditosilate QLNC-120 Phase 2 Clinical Qilu Antibiotics (Linyi) Pharmaceutical Co Ltd, Qilu Pharmaceutical Co Ltd Breast Neoplasms Details Pimurutamab HLX-07 Phase 2 Clinical Shanghai Henlius Biotech Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Stomach Neoplasms; Esophageal Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Adenosquamous; Carcinoma, Basosquamous; Nasopharyngeal Carcinoma; Colorectal Neoplasms; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details NRC-2694 NRC-2694; NRC-2694A; NRC-2694-A Phase 2 Clinical Natco Pharma Carcinoma; Squamous Cell Carcinoma of Head and Neck Details Bafisontamab FIT-013a; EMB-01 Phase 2 Clinical Shanghai Epimab Biotherapeutics, Inc Biliary Tract Neoplasms; Liver Neoplasms; Carcinoid Tumor; Stomach Neoplasms; Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 Phase 2 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Colorectal Neoplasms Details GB-263 GB-263; GB-263T Phase 2 Clinical Genor Biopharma Co Ltd Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details ORIC-114 ORIC-114; VRN-07 Phase 2 Clinical Voronoi Inc Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details WJ-13404 WJ-13404; JS-113; WJ-004 Phase 2 Clinical Wigen Biomedicine technology (Shanghai) Co Ltd Carcinoma, Non-Small-Cell Lung Details BDTX-1535 BDTX-1535 Phase 2 Clinical Black Diamond Therapeutics Inc Glioblastoma; Glioma; Carcinoma, Non-Small-Cell Lung Details Neratinib (Fukang (Shanghai) Health Technology) CVL009; CVL-009 Phase 2 Clinical Fukang (Shanghai) Health Technology Co Ltd Solid tumours; Uterine Neoplasms; Carcinoma, Non-Small-Cell Lung Details IBI-3001 IBI-3001; IBI3001 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details TRX-221 TRX-221 Phase 2 Clinical Therapex Corp Carcinoma, Non-Small-Cell Lung Details E-EDV-D682 PNU-15982; E-EDV-D682; EGFR-EDV-PNU-15982 Phase 2 Clinical Engeneic Ltd Pancreatic Neoplasms Details IBI334 IBI334; IBI-334 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details DWP-708 DWP-708 Phase 2 Clinical Daewoong Pharmaceutical Co Ltd Acneiform Eruptions Details BBT-207 BBT-207 Phase 2 Clinical Bridge Biotherapeutics Inc Carcinoma, Non-Small-Cell Lung Details H-002 H-002 Phase 2 Clinical Nanjing Hongyun Biological Technology Co Ltd Neoplasms; Carcinoma, Non-Small-Cell Lung Details DAJH-1050766 DAJH1050766; DAJH-1050766 Phase 2 Clinical Chengdu Diao Jiuhong Pharmaceutical Factory Carcinoma, Non-Small-Cell Lung Details Anti-CTLA-4/PD-1 expressing EGFR-CAR-T Phase 2 Clinical Shanghai Cell Therapy Research Institute Solid tumours Details IAE-0972 IAE-0972 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Carcinoma, Hepatocellular Details Anti-EGFR CAR-T cell therapy (Beijing Pregene) Phase 2 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details BAY-2927088 BAY-2927088; BAY2927088 Phase 2 Clinical Bayer AG, Broad Institute, Harvard University Carcinoma, Non-Small-Cell Lung Details HS-10375 HS-10375 Phase 2 Clinical Jiangsu Hansoh Pharmaceutical Group Co Ltd Carcinoma, Non-Small-Cell Lung Details SMET-12 SMET-12 Phase 2 Clinical Zhejiang Shimai Pharmaceutical Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details EO-1001 NT-113; APL-122 Phase 2 Clinical Edison Pharmaceuticals Inc Neoplasms Details TAK-186 EGFR x CD3 COBRA; MVC-101; TAK-186 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details AP-L1898 JS111; WJ-002; AP-L1898 Phase 2 Clinical Wigen Biomedicine technology (Shanghai) Co Ltd Small Cell Lung Carcinoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details BPI-361175 BPI-361175 Phase 2 Clinical Betta Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details CKD-702 Phase 2 Clinical Chong Kun Dang Pharmaceutical Corp Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details REGN-7075 REGN-7075 Phase 2 Clinical Regeneron Pharmaceuticals Inc Solid tumours Details JRF-103 JRF103; JRF-103 Phase 2 Clinical Shenzhen Jinrui Foundation Biotechnology Co Ltd Solid tumours Details Anti-EGFR-IL-dox (Swiss Group for Clinical Cancer Research) Phase 2 Clinical Schweizerische Arbeitsgemeinschaft Für Klinische Krebsforschung Breast Neoplasms Details FCN-411 FCN-411 Phase 2 Clinical Shanghai Fosun Pharmaceutical (Group) Co Ltd Small Cell Lung Carcinoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details Epertinib S-222611 Phase 2 Clinical Shionogi & Co Ltd Neoplasms Details Pirotinib Hydrochloride KBP-5209 Phase 2 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Solid tumours; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details Humanized anti-EGFR monoclonal antibody (Hualan Biological Engineering/Henan shengming biotechnology) Phase 2 Clinical Henan Shengming Biotechnology Research Institute Co Ltd, Hualan Genetic Engineering Co Ltd Colorectal Neoplasms Details Anti-CD3/anti-EGFR -activated T cells (Barbara Ann Karmanos Cancer Institute) Phase 2 Clinical Barbara Ann Karmanos Cancer Institute, University Of Virginia Glioblastoma; Pancreatic Neoplasms Details Cetuximab biosimilar (Guilin Sanjin) CDP-1; BC-001 Phase 1 Clinical Dragonboat Biopharmaceutical, Guilin Sanjin Pharmaceutical Co Ltd Solid tumours; Neoplasms; Colorectal Neoplasms Details TQB3804 TQB-3804 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Neoplasms; Carcinoma, Non-Small-Cell Lung Details D2C7-based immunotoxins (Duke University) D2C7-IT; scds-D2C7 -PE38KDEL; D2C7-(scdsFv)-PE38 KDEL Phase 1 Clinical Istari Oncology Inc, Duke University Glioma Details Anti-EGFR CAR T-cell therapy (Seattle Children's Hospital) EGFR-806 Phase 1 Clinical Seattle Children'S Hospital Sarcoma, Synovial; Neoplasms, Germ Cell and Embryonal; Diffuse Intrinsic Pontine Glioma; Retinoblastoma; Neuroblastoma; Sarcoma; Neurofibrosarcoma; Sarcoma, Ewing; Osteosarcoma; Sarcoma, Clear Cell; Rhabdomyosarcoma; Central Nervous System Neoplasms; Wilms Tumor; Carcinoma; Rhabdoid Tumor; Hepatoblastoma; Desmoplastic Small Round Cell Tumor; Diffuse midline glioma; Solid tumours Details BPI-15086 BPI-15086; BPI-15000 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details Recombinant anti-human EGFR antibody/IL-10 bispecific Fc fusion protein(Dingfu Biotarget) CmAb-(IL10)2; DF203; DF-203 Phase 1 Clinical Dingfu Biotarget Co Ltd Solid tumours Details MP-0274 DARPin-41; SPA-28; CME-114; CME-115; CME-118; CME-119; MP-0274 Phase 1 Clinical Molecular Partners Ag Neoplasms Details SYN-004 (Synermore Biologics) LR-004; SYN-004 Phase 1 Clinical Lonn Ryonn Pharma Ltd, Synermore Biologics (Suzhou) Co Ltd Solid tumours; Carcinoma; Lymphoma, Large B-Cell, Diffuse; Colorectal Neoplasms Details KY-1701 KY-1701 Phase 1 Clinical Jiangsu Kanion Pharmaceutical Co Ltd Breast Neoplasms Details Simotinib Hydrochloride AL-6802; SIM-6802 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Advenchen Laboratories Llc Carcinoma, Non-Small-Cell Lung Details Double-deleted Vaccinia Virus Plus CD/ SMR JX-929; vvDD-CDSR Phase 1 Clinical Sillajen Inc Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Melanoma Details WSD-0922 WSD-0922; WSD0922 Phase 1 Clinical Wayshine Biopharm International Ltd Glioblastoma; Neoplasms; Astrocytoma; Carcinoma, Non-Small-Cell Lung Details TQ-B3395 TQ-B3395; CT-1495; TQ-B-3395 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Beijing Centaurus Biopharma Co Ltd Neoplasms; Breast Neoplasms Details Antibody-drug nanocell conjugates (EnGeneIC) EGFR-EDV-RRM1; EGFR-EDV-PLK; EGFR-EDV-Dox Phase 1 Clinical Engeneic Ltd Glioblastoma Details Cetuximab biosimilar (Shanghai Henlius Biotech) HLX-05; JZB-29; JZB-28 Phase 1 Clinical Shanghai Henlius Biotech Inc Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms Details Recombinant chimeric anti-EGFR monoclonal antibody (Zhejiang Xinwei Shengke Biotechnology) Phase 1 Clinical Zhejiang Xinweishengke Biotechnology Co Ltd Esophageal Neoplasms Details Anti-EGFR-bispecific antibody armed activated T-cell therapy (Memorial Sloan Kettering Cancer Center) Phase 1 Clinical Memorial Sloan Kettering Cancer Center Pancreatic Neoplasms Details [89Zr]Panitumumab Phase 1 Clinical Vanderbilt-Ingram Cancer Center, University Of Alabama At Birmingham, Stanford University Squamous Cell Carcinoma of Head and Neck; Colonic Neoplasms; Pancreatic Neoplasms Details Recombinant chimeric anti-EGFR monoclonal antibody (Qilu Pharmaceutical) QL-1105 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details EGFRvIII-CAR Phase 1 Clinical Duke University Medical Center Glioblastoma Details 14C-labeled poziotinib Phase 1 Clinical Spectrum Pharmaceuticals Solid tumours Details BB-101 (Blue Blood Biotech/National Cheng Kung University) BB-101 Phase 1 Clinical National Cheng Kung University, Blue Blood Biotech Corp Diabetic Foot Details Puvitinib Phase 1 Clinical Suzhou Teligene Ltd Solid tumours Details Betatinib TL-512 Phase 1 Clinical Aspedia Llc, Suzhou Teligene Ltd Carcinoma, Non-Small-Cell Lung Details KSP-QRH-E3-IRDye800 Phase 1 Clinical University Of Michigan Cholangiocarcinoma Details Hemay-020 Hemay-020 Phase 1 Clinical Tianjin Hemay Pharmaceutical Co Ltd, Hainan General Sanyang Pharmaceutical Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details SGT-210 SGT-210 Phase 1 Clinical Sol Gel Technologies Pte Ltd Keratosis Details Epitinib Succinate HMPL-813 Phase 1 Clinical Hutchison Medipharma Ltd Solid tumours; Neoplasms; Glioblastoma; Carcinoma, Non-Small-Cell Lung Details ZN-e4 ZN-e4; KP-673 Phase 1 Clinical Zentalis Pharmaceuticals LLC, Zeno Pharma Carcinoma, Non-Small-Cell Lung Details LY-01010 LY-01010 Phase 1 Clinical Luye Pharma Group Ltd Breast Neoplasms Details PB-357 PB-357 Phase 1 Clinical Pfizer Inc Neoplasms Details ZSP-0391 ZSP-0391 Phase 1 Clinical Wuxi Apptec Co Ltd, Guangdong Zhongsheng Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details Neptinib Di-P-methylbenzenesulfonate Phase 1 Clinical Shenzhen Neptunus Pharmaceutical Research Institute Co Ltd Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details QRH-882260 QRH-882260 Phase 1 Clinical University Of Michigan Cholangiocarcinoma Details Serclutamab talirine ABBV-321 Phase 1 Clinical Abbvie Inc Neoplasms Details Recombinant anti-EGFR chimeric antibody (Harbin Pharmaceutical) Phase 1 Clinical Harbin Pharmaceutical Group Holding Co Ltd Colorectal Neoplasms Details Diakine-DK2 10 (EGFR) DK210; DK-2-10 Phase 1 Clinical Deka Biosciences Inc Kidney Neoplasms; Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Skin Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Carcinoma, Non-Small-Cell Lung Details HLX-42 HLX-42; HLX42 Phase 1 Clinical Hanlin Biotechnology Co Ltd Solid tumours; Neoplasms Details CMAB-017 CMAB-017 Phase 1 Clinical Taizhou Mabtech Pharmaceutical Co Ltd Solid tumours Details JY-016 JY-016 Phase 1 Clinical Beijing Jingyitaixiang Technology Development Co Ltd, Beijing Eastern Biotech Co Ltd Solid tumours; Colorectal Neoplasms; Lung Neoplasms Details PF-08046052 SGN-EGFRd2; LAVA-1223 Phase 1 Clinical Vu University Medical Center, Lava Therapeutics NV, Seagen Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details CM-93 CM-93 Phase 1 Clinical Shanghai Crimson Pharmaceutical Co Ltd Glioblastoma Details BLU-701 BLU-701; BLU 701 Phase 1 Clinical Blueprint Medicines Corp Carcinoma, Bronchogenic; Carcinoma; Thoracic Neoplasms; Bronchial Neoplasms; Neoplasms; Respiratory Tract Diseases; Lung Diseases; Respiratory Tract Neoplasms; Neoplasms, Nerve Tissue; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details CX-904 CX-904 Phase 1 Clinical Amgen Inc, Cytomx Therapeutics Inc Solid tumours; Neoplasms Details Cetuximab biosimilar (Humanwell Healthcare) Phase 1 Clinical Humanwell Healthcare (Group) Co Ltd Colorectal Neoplasms Details Sirotinib Maleate XZP-5491 Phase 1 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Stomach Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details Tomuzotuximab GT-MAB-5.2-GEX Phase 1 Clinical Glycotope Gmbh Solid tumours; Squamous Cell Carcinoma of Head and Neck Details YL-221 YL221; YL-221 Phase 1 Clinical MediLink Therapeutics Co Ltd Solid tumours Details [14C]-PLB1004 [14C]-PLB1004 Phase 1 Clinical Beijing Avistone Pharmaceuticals Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details FPI-2107 [111In]-FPI-2107 Phase 1 Clinical Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details FPI-2053 FPI-2053 Phase 1 Clinical Astrazeneca Plc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details CPO-301 CPO301; CPO-301 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Solid tumours; Neoplasms; Lung Neoplasms Details FPI-2068 [225Ac]-FPI-2068; FPI-2068 Phase 1 Clinical Astrazeneca Plc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details HS-20117 HS-20117; PM1080; PM-1080 Phase 1 Clinical Biotheus Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details SYS-6010 SYS6010; SYS-6010 Phase 1 Clinical Jushi Biopharmaceutical Co Ltd Solid tumours Details SNC-109 SNC109; SNC-109 Phase 1 Clinical Shanghai Simnova Biotechnology Co Ltd Glioblastoma Details HSK-40118 HSK40118; HSK-40118 Phase 1 Clinical Haisco Pharmaceutical Group Co Ltd Carcinoma, Non-Small-Cell Lung Details AZD9592 AZD-9592; AZD9592 Phase 1 Clinical Astrazeneca Plc Solid tumours; Head and Neck Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details JANX-008 EGFR-TRACTr; JANX008; JANX-008 Phase 1 Clinical Janux Therapeutics Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details TAVO-412 TAVO-412 Phase 1 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd, Tuochuang Biotechnology (Jiangsu) Co Ltd Solid tumours; Neoplasms Details NX-019 NX-019 Phase 1 Clinical Nalo Therapeutics Inc Neoplasms Details QLH-11811 QLH-11811; QLH11811 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details Losatuxizumab vedotin ABBV-221; ABBV221 Phase 1 Clinical Abbvie Inc Neoplasms Details EGFR/B7H3 CAR-T EGFR/B7H3 CAR-T Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Triple Negative Breast Neoplasms; Lung Neoplasms Details BB-1705 BB-1705 Phase 1 Clinical Bliss Biopharmaceutical (Hangzhou) Co Ltd Solid tumours; Neoplasms; Neoplasm Metastasis Details CART-EGFR-IL13Ra2 CART-EGFR-IL13Ra2; CAR-T-EGFR-IL-13-Ra-2 Phase 1 Clinical University Of Pennsylvania Glioblastoma Details BNA-035 BNA-035 Phase 1 Clinical Binacea Pharma Inc Solid tumours Details EGFR IL12 CART Phase 1 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details ERAS-801 ERAS-801 Phase 1 Clinical Regents Of The University Of California Glioblastoma Details NIP-142 NIP-142 Phase 1 Clinical National Institutes Of Pharmaceutical Research And Development Co Ltd Carcinoma, Non-Small-Cell Lung Details TAS-2940 TAS-2940 Phase 1 Clinical Taiho Oncology Inc Solid tumours; Glioblastoma; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details [111In] Panitumumab Phase 1 Clinical Stanford University Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck Details BC-3448 BC3448; BC-3448 Phase 1 Clinical Solid tumours Details ABBV-637 ABBV-637 Phase 1 Clinical Abbvie Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details M-1231 M-1231 Phase 1 Clinical Emd Serono Research & Development Institute Inc, Merck Serono Solid tumours; Esophageal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details HLX-35 HLX-35 Phase 1 Clinical Shanghai Henlius Biologics Co Ltd Solid tumours; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details WTS-004 WTS-004 Phase 1 Clinical Hangzhou Wutong Tree Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details ES-072 ES-072 Phase 1 Clinical Zhejiang Bosheng Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details ZZ-06 ZZ-06 Phase 1 Clinical Changchun Intellicrown Pharmaceutical Co Ltd Solid tumours Details ABY-029 ABY-029 Phase 1 Clinical Dartmouth College, Affibody Ab, Li-Cor Bioscience Head and Neck Neoplasms; Sarcoma; Glioma Details Lifirafenib BeiGene-283; BGB-283 Phase 1 Clinical Beigene Ltd Solid tumours Details Cetuximab biosimilar (Enzene Biosciences) Clinical Enzene Biosciences Ltd Carcinoma, Squamous Cell Details VRN-11 VRN11 Clinical Voronoi Inc Carcinoma, Non-Small-Cell Lung Details