丁能, 付新新, 吴海媚, 等. 甲基丙烯酸酐化明胶水凝胶在创面修复领域中的应用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(11): 1096-1100. DOI: 10.3760/cma.j.cn501225-20220308-00056. 引用本文: 丁能, 付新新, 吴海媚, 等. 甲基丙烯酸酐化明胶水凝胶在创面修复领域中的应用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(11): 1096-1100. DOI: 10.3760/cma.j.cn501225-20220308-00056 . Ding N,Fu XX,Wu HM,et al.Research progress of the application of methacrylic anhydride gelatin hydrogel in wound repair[J].Chin J Burns Wounds,2022,38(11):1096-1100.DOI: 10.3760/cma.j.cn501225-20220308-00056. Citation: Ding N,Fu XX,Wu HM,et al.Research progress of the application of methacrylic anhydride gelatin hydrogel in wound repair[J].Chin J Burns Wounds,2022,38(11):1096-1100.DOI: 10.3760/cma.j.cn501225-20220308-00056 . 丁能, 付新新, 吴海媚, 等. 甲基丙烯酸酐化明胶水凝胶在创面修复领域中的应用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(11): 1096-1100. DOI: 10.3760/cma.j.cn501225-20220308-00056. 引用本文: 丁能, 付新新, 吴海媚, 等. 甲基丙烯酸酐化明胶水凝胶在创面修复领域中的应用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(11): 1096-1100. DOI: 10.3760/cma.j.cn501225-20220308-00056 . Ding N,Fu XX,Wu HM,et al.Research progress of the application of methacrylic anhydride gelatin hydrogel in wound repair[J].Chin J Burns Wounds,2022,38(11):1096-1100.DOI: 10.3760/cma.j.cn501225-20220308-00056. Citation: Ding N,Fu XX,Wu HM,et al.Research progress of the application of methacrylic anhydride gelatin hydrogel in wound repair[J].Chin J Burns Wounds,2022,38(11):1096-1100.DOI: 10.3760/cma.j.cn501225-20220308-00056 . 创面修复是临床中常见难题，严重影响患者生活质量，也给社会带来沉重负担。基于水凝胶开发的多功能敷料在治疗急性和慢性创面中显示了较强的潜力。甲基丙烯酸酐化明胶（GelMA）水凝胶除具备良好的组织相容性、细胞黏附性和生物可降解性等优势外，还因成本低廉、反应条件温和、理化性质可调节、临床应用广泛等而备受关注。该文介绍了GelMA水凝胶的特征及其在创面修复领域中的应用研究进展，并对用于治疗创面的多功能GelMA水凝胶敷料的未来发展进行了展望。

生物敷料 /  水凝胶 /  组织工程 /  甲基丙烯酸酐化明胶 / Abstract: Wound repair is a common clinical problem, which seriously affects the quality of life of patients and also brings a heavy burden to the society. Hydrogel-based multifunctional dressing has shown strong potential in the treatment of acute and chronic wounds. In addition to its good histocompatibility, cell adhesion, and biodegradability, methacrylic anhydride gelatin (GelMA) hydrogel has also attracted much attention due to its low cost, mild reaction conditions, adjustable physicochemical properties, and wide clinical applications. In this paper, the characteristics of GelMA hydrogel and its research progress in wound repair are introduced, and the future development of multifunctional GelMA hydrogel dressing for wound treatment is prospected.

Key words: Biological dressings /  Hydrogel /  Tissue engineering /  Gelatin methacryloyl /  Wound repair

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