引用本文: 黄亚军, 张艳彬, 赵艳丽, 等. 妊娠期生殖道B族链球菌感染患者阴道微生态、 血清炎性因子变化及母婴结局调查[J]. 中国微生态学杂志, 2020, 32(4): 455-460. doi: 10.13381/j.cnki.cjm.202004018 Citation: HUANG Yajun, ZHANG Yanbin, ZHAO Yanli, et al. Changes of vaginal microecology, serum inflammatory factors and maternal and child outcomes in patients with group B Streptococcus infection during pregnancy[J]. Chinese Journal of Microecology, 2020, 32(4): 455-460. doi: 10.13381/j.cnki.cjm.202004018

Changes of vaginal microecology, serum inflammatory factors and maternal and child outcomes in patients with group B Streptococcus infection during pregnancy

HUANG Yajun , ZHANG Yanbin , ZHAO Yanli , REN Na , ZHANG Xueling

Department of Obstetrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China, Department of Obstetrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China, Department of Obstetrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China, Department of Obstetrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China and Department of Obstetrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China

目的 探讨妊娠期生殖道B族链球菌(GBS)感染患者阴道微生态、血清炎性因子变化及其对母婴结局的影响。 方法 对482例妊娠妇女的临床资料展开回顾,统计妊娠期生殖道GBS感染情况,并将其分为感染组(GBS细菌培养阳性)和非感染组(GBS细菌培养阴性),其中感染组患者给予抗生素药物治疗。统计妊娠期生殖道GBS感染检出情况；分析并比较感染组与非感染组阴道微生态分布情况；检测感染组与非感染组及感染组治疗前后血清炎性因子的变化情况；统计感染组的治疗效果；分析并比较感染组与非感染组母婴结局情况；分析影响母婴结局的危险因素。 结果 医院收治的482例妊娠期患者中检出生殖道GBS细菌培养阳性68例,阳性率为14.11%。感染组的阴道微生态环境中GBS、白细胞酯酶、唾液酸酶、乙酰氨基葡萄糖苷酶、脯氨酸氨基肽酶、过氧化氢酶检出率均高于非感染组(均P0.05),感染组早产、胎膜早破、羊水污染发生率均高于非感染组(均P0.05),感染组围产儿宫内窘迫、生理性黄疸发生率均显著高于非感染组(均P结论 妊娠期生殖道GBS感染患者的阴道微生态菌群改变,血清炎性因子升高,可增加母婴不良结局的发生风险。 B族链球菌 生殖道感染 阴道微生态 血清炎性因子 Abstract: Objective To investigate the changes of vaginal microecology, serum inflammatory factors and their effects on maternal and child outcomes in patients with genital group B Streptococcus (GBS) infection during pregnancy. Methods The clinical data of 482 pregnant women during pregnancy were reviewed and divided into infection group (positive for GBS bacterial culture) or non infection group (negative for GBS bacterial culture). Patients in the infection group were given antibiotic therapy. The detection of GBS infection during pregnancy was counted. The distribution of vaginal microecology was analyzed and compared between the two groups. The changes of serum inflammatory factors in both groups before and after treatment were detected. Treatment effect in infection group was statistically analyzed. The maternal and child outcomes were analyzed and compared between groups. The risk factors affecting maternal and infant outcomes were analyzed. Results Among the 482 pregnant patients, 68 (14.11%) were positive for GBS infection. The detection rates of GBS, leucocyte esterase, sialidase, acetaminopsidase, proline aminopeptidase and catalase in the infection group were higher than those in the non infection group (all P0.05), and those of preterm birth, premature rupture of membranes and amniotic fluid pollution were significant higher (all P0.05), and those of intrauterine distress and physiological jaundice were significantly higher (all PConclusion Changes in vaginal flora and serum inflammatory factors in patients with GBS infection of reproductive tract during pregnancy can increase the risk of adverse outcomes of mothers and children. Keywords: Pregnancy Group B Streptococcus Genital tract infection Vaginal microecology Serum inflammatory factor Mother son outcome 王晓娜, 丛桂敏, 佟成龙, 等.B族链球菌感染妊娠妇女产时抗生素治疗临床效果评价[J].中国微生态学杂志, 2019,31(8):907 909.WANG Xiaona, CONG Guimin, TONG Chenglong, et al.The clinical effect of antibiotic treatment during pregnancy and maternity of pregnant women with B group streptococcal infection[J].Chin J Microecol, 2019,31(8):907 909.(in Chinese) 林开婷, 管翠, 陈坚, 等.妊娠晚期孕妇B族溶血性链球菌感染对孕产妇凝血功能及母婴结局的影响[J].中华医院感染学杂志, 2017,27(19):4511 4514.LIN Kaiting, GUAN Cui, CHEN Jian, et al.Effect of group B hemolytic Streptococcus infections on maternal coagulation function and maternal and child outcomes in pregnant women late pregnancy[J].Chin J Nosocomiol, 2017,27(19):4511 4514.(in Chinese)