干扰素基因刺激蛋白(STING)是新发现的天然免疫系统中的重要接头蛋白,在细胞质DNA介导天然免疫反应中发挥重要作用。胞内双链DNA识别受体均通过STING介导产生Ⅰ型干扰素以及其他细胞因子。天然免疫和抗HBV特异免疫应答不足是HBV慢性感染的关键原因。介绍了STING的发现及其结构研究的最新进展,并简要阐述了STING信号通路的活化机制。总结了国内外研究团队在STING信号通路与HBV相互作用方面的研究进展,并指出了其在临床治疗方面的潜在价值。
肝炎病毒,乙型 /
衔接蛋白质类,信号转导 /
免疫,天然 /
Abstract:
Stimulator of interferon genes ( STING) is a newly discovered adaptor protein in the innate immune system and plays an important role in innate immune response mediated by cytoplasmic DNA. Double-stranded DNA recognition receptors in cells are mediated by STING protein to produce type I interferon and other cytokines. Inadequate innate immune response and anti-hepatitis B virus ( HBV) specific immune response are important causes of chronic HBV infection. This article introduces the discovery of STING and the latest research advances in its structure, briefly elaborates on the mechanism of activation of the STING signaling pathway, summarizes the research advances in the interaction between the STING signaling pathway and HBV, and points out the potential value of STING in clinical treatment.
Key words:
hepatitis B virus /
adaptor proteins, signal transducing /
immunity, natural /
review
