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- Anti-infection 抗感染
- ADC Related 抗体偶联药物相关
- Apoptosis 凋亡
- Autophagy 自噬
- Cell Cycle/DNA Damage 细胞周期/DNA 损伤
- Cytoskeleton 细胞骨架
- Epigenetics 表观遗传学
- GPCR/G Protein G 蛋白偶联受体/G 蛋白
- Immunology/Inflammation 免疫及炎症
- JAK/STAT Signaling JAK/STAT 信号通路
- MAPK/ERK Pathway MAPK/ERK 信号通路
- Membrane Transporter/Ion Channel 跨膜转运
- Metabolic Enzyme/Protease 代谢酶/蛋白酶
- Neuronal Signaling 神经信号通路
- NF-κB NF-κB 信号通路
- PI3K/Akt/mTOR PI3K/Akt/mTOR 信号通路
- PROTAC 蛋白降解靶向嵌合体
- Protein Tyrosine Kinase/RTK 蛋白酪氨酸激酶
- Stem Cell/Wnt 干细胞及 Wnt 通路
- TGF-beta/Smad TGF-beta/Smad 信号通路
- Vitamin D Related/Nuclear Receptor 维生素 D 相关/核受体
- Others 其他
Anti-infection
Apoptosis
Cell Cycle/DNA Damage
Epigenetics
- AMPK
- Aurora Kinase
- DNA Methyltransferase
- Epigenetic Reader Domain
- Glycosyltransferase
- HDAC
- Histone Acetyltransferase
- Histone Demethylase
- Histone Methyltransferase
- HuR
- JAK
- Methionine Adenosyltransferase (MAT)
- METTL3
- MicroRNA
- PARP
- PKC
- Protein Arginine Deiminase
- SF3B1
- Sirtuin
- Small Interfering RNA (siRNA)
GPCR/G Protein
- 5-HT Receptor
- Adenylate Cyclase
- Adrenergic Receptor
- Amylin Receptor
- Angiotensin Receptor
- Apelin Receptor (APJ)
- Arrestin
- Bombesin Receptor
- Bradykinin Receptor
- Cannabinoid Receptor
- CaSR
- CCR
- CGRP Receptor
- Chemerin Receptor
- Cholecystokinin Receptor
- CRFR
- CXCR
- EBI2/GPR183
- Endothelin Receptor
- Formyl Peptide Receptor (FPR)
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
- 11β-HSD
- 15-PGDH
- 17β-HSD
- 5 alpha Reductase
- Acetolactate Synthase (ALS)
- Acetyl-CoA Carboxylase
- Acyltransferase
- ADAMTS
- Adiponectin Receptor
- Aldehyde Dehydrogenase (ALDH)
- Aldose Reductase
- Aminoacyl-tRNA Synthetase
- Aminopeptidase
- Amylases
- Angiotensin-converting Enzyme (ACE)
- ANGPTL
- Arginase
- ATGL
- ATP Citrate Lyase
- Carbonic Anhydrase
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
- Cytokines and Growth Factors 细胞因子和生长因子
- Immune Checkpoint Proteins 免疫检查点蛋白
- CAR-T related Proteins CAR-T 相关蛋白
- CD Antigens CD 抗原
- Fc Receptors Fc 受体蛋白
- Receptor Proteins 受体蛋白
- Enzymes & Regulators 酶和调节子
- Complement System 补体系统
- Ubiquitin Related Proteins 泛素相关蛋白
- Viral Proteins 病毒蛋白
- Biotinylated Proteins 生物素标记蛋白
- Fluorescent-labeled Proteins 荧光标记蛋白
- GMP-grade Proteins GMP 级蛋白
- Animal-free Recombinant Proteins 无动物成分重组蛋白
- Others 其他
- View More
CAR-T related Proteins
- B Cell Maturation Antigen (BCMA)
- FLK-1/VEGFR-2
- B7-H3
- CD4
- CD19
- CD123
- CD138/Syndecan-1
- Epithelial Cell Adhesion Molecule (EpCAM)
- Folate Receptor 1
- GPC-3
- Guanylate Cyclase 2C
- ErbB2/HER2
- ErbB3/HER3
- c-Met/HGFR
- MSLN
- CA-125
- ROR1
- CEACAM-5
- Natural Killer Group 2, Member D (NKG2D)
- Prostate Specific Membrane Antigen
- CRACC/SLAMF7
- TROP-2
- Siglec-6
- Folate Receptor alpha (FR-alpha)
- CD33
- CD70
- CD138/Syndecan-1
- CD138/Syndecan-1
- Nectin-4
- Carbonic Anhydrase 9 (CA IX)
- EGFR
- FLK-1/VEGFR-2
- CD7
- CD20
- Siglec-2/CD22
- CD30
- CD38
- MUC-1/CD227
CD Antigens
- T Cell CD Proteins
- B Cell CD Proteins
- NK Cell CD Proteins
- Macrophage CD Proteins
- Monocyte CD Proteins
- Stem Cell CD Proteins
- Platelet CD Proteins
- Erythrocyte CD Proteins
- Dendritic Cell CD Proteins
- Epithelial cell CD Proteins
- Endothelial cell CD Proteins
- Signal Transduction-related CD Proteins
- Cell Adhesion-related CD Proteins
Receptor Proteins
- Receptor Tyrosine Kinases
- Receptor Serine/Threonine Kinases
- Receptor Tyrosine Phosphatase
- Receptor Guanylyl Cyclase Family
- Cell Adhesion Molecules (CAMs)
- G-Protein-Coupled Receptors (GPCRs)
- Nuclear Receptor Superfamily
- Pattern Recognition Receptors
- Notch family
- Siglec
- Leukocyte Immunoglobin-like Receptors
- Killer-Cell Immunoglobulin-like Receptors
- Cytokine Receptors
Enzymes & Regulators
- Oxidoreductases (EC 1)
- Transferases (EC 2)
- Hydrolases (EC 3)
- Lyases (EC 4)
- Isomerases (EC 5)
- Ligases (EC 6)
- Translocases (EC 7)
- Matrix Metalloproteinases
- ADAMs/ADAMTSs
- Cathepsin
- Carboxypeptidase
- Angiotensin-converting Enzymes
- Caspase
- Carbonic Anhydrase
- Serine/Threonine Kinase Proteins
- Protein Tyrosine Kinases
- Phosphatase
- Topoisomerase
- Protease Inhibitors
- Protein Kinase Inhibitor Peptide (PKI)
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cystatin Family
Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.
STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.
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