引文著录:
许会丽, 张连峰, 周琳. 嗜酸性粒细胞性胃肠炎98例临床特点与诊治.
世界华人消化杂志
2017; 25(36): 3224-3229
Clinical characteristics, diagnosis, and treatment of 98 cases of eosinophilic gastroenteritis
Hui-Li Xu, Lian-Feng Zhang, Lin-Zhou
Hui-Li Xu, Lian-Feng Zhang, Lin-Zhou,
Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, He'nan Province, China
Supported by
:
National Natural Science Foundation of China
, No.
81472325
.
Correspondence to
: Lian-Feng Zhang, Professor, Chief Physician, Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Erqi District, Zhengzhou 450052, He'nan Province, China.
[email protected]
Received:
November 2, 2017
Revised:
November 22, 2017
Accepted:
December 3, 2017
Published online:
December 28, 2017
AIM
To investigate the clinical characteristics of eosinophilic gastroenteritis (EG) in order to improve the understanding of EG and reduce the rates of misdiagnosis and missed diagnosis.
METHODS
A retrospective analysis was performed of the clinical manifestations, laboratory examinations, endoscopic findings, treatment, and prognosis of 98 patients diagnosed with EG at the First Affiliated Hospital of Zhengzhou University from June 2011 to May 2017.
RESULTS
Main clinical manifestations of EG were abdominal pain (85/98). Mucosal type (82/98) was the most common type. Increased peripheral blood eosinophils and bone marrow eosinophils might be suggestive of EG. Endoscopic findings, mainly in the stomach, were not specific. Endoscopic biopsy showed massive eosinophil infiltration. A large number of eosinophils were observed in the ascites of patients with the serous type. Both hormone therapy and non-hormone therapy had good efficacy, and the hormone treatment group had obviously decreased eosinophils. Hormone therapy was still effective in the case of relapse.
CONCLUSION
Due to the lack of specific clinical manifestations, EG may be misdiagnosed. Massive eosinophil infiltration in endoscopic biopsy and ascites is the key to the diagnosis, and glucocorticoids are the preferred therapeutic drugs.
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