You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page . Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands E-mail: Floris.Rutjes@ru.nl Bio-organic chemistry, Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands E-mail: J.C.M.v.Hest@tue.nl

During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

V. R. L. J. Bloemendal, M. A. C. H. Janssen, J. C. M. van Hest and F. P. J. T. Rutjes, React. Chem. Eng. , 2020, 5 , 1186 DOI: 10.1039/D0RE00087F

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