2010-2013
天津大学化工学院，工学硕士
2013-2018
荷兰莱顿大学药学院，药剂学博士
2018-2022
四川大学华西药学院，博士后、副研究员（专职科研），合作导师
:
孙逊教授
2022-
至今
四川大学华西药学院药剂系，副研究员
研究方向
:
1.
微针药物递送系统的研究
2.
新型疫苗和佐剂递送系统的研究
科研项目：
1.
国家自然科学基金专项项目，
2023 - 2025
，主持
2.
国家自然科学基金青年基金，
2021 - 2023
，主持
3.
四川省自然科学基金青年基金，
2022 - 2023
，主持
4.
教育部博士后基金面上项目，
2020 - 2021
，主持
1.
2023
年第十八届
“
挑战杯
”
全国大学生课外学术科技作品竞赛一等奖指导教师
2.
2023
年第十七届
“
挑战杯
”
四川省大学生课外学术科技作品竞赛特等奖指导教师
3.
2022
年四川大学华西药学院“红叶实验奖学奖教金”
代表性研究论文：
1.
Xuanyu Wang
#
, Xiaofang Zhong
#
, Zhiqiang Xie, Yuanhao Zhao, Hairui Wang, Zhirong Zhang, Tao Gong,
Guangsheng Du*
, Xun Sun*. A trinity strategy: Mesoporous platinum nanoparticles serve as a photoenhanced nanoplatform for tumor immunotherapy.
Chemical Engineering Journal
, 2024, 495:153365.
2.
Jiaxuan Zhao, Penghui He, Min Jiang, Chunting He, Yuanhao Zhao, Zhihua Zhang, Zhibing Zhang,
Guangsheng Du*
, Xun Sun*. Transdermally delivered tolerogenic nanoparticles induced effective immune tolerance for asthma treatment.
Journal of Controlled Release
, 2024, 366:637-649.
3.
Yuanhao Zhao, Xiaoyan Chen, Penghui He, Xuanyu Wang, Yanhua Xu, Rui Hu, Yangsen Ou, Zhihua Zhang, Zhibing Zhang,
Guangsheng Du*
, Xun Sun*. Transdermal microneedles alleviated rheumatoid arthritis by inducing immune tolerance via skin-resident antigen presenting cells.
Small
, 2023:2307366.
4.
Guangsheng Du
, Ming Qin, Xun Sun*. Recent progress in application of nanovaccines for enhancing mucosal immune responses.
Acta Pharmaceutica Sinica B
, 2023, 13:2334-2345.
5.
Zhengjun Chen, Xinyan Hao, Hairui Wang, Xiaofang Zhong, Xiaoyan Chen, Yuanhao Zhao, Yuandong Zhang,
Guangsheng Du*
, Xun Sun*. Smart combination of aluminum hydroxide and MF59 to induce strong cellular immune responses.
Journal of Controlled Release
, 2022, 349:699-711.
6.
Guangsheng Du,
Penghui He, Jiaxuan Zhao, Chunting He, Min Jiang, Zhihua Zhang, Zhibing Zhang, Xun Sun*. Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment.
Journal of Controlled Release
, 2021, 336:537-548.
7.
Ming Qin,
Guangsheng Du*
,
Xun Sun*. Recent advances in the noninvasive delivery of mRNA.
Accounts of Chemical Research
, 2021, 54:4262-4271.
8.
Guangsheng Du,
Zhihua Zhang, Penghui He, Zhibing Zhang*, Xun Sun*. Determination of the mechanical properties of polymeric microneedles by micromanipulation.
Journal of the Mechanical Behavior of Biomedical Materials
, 2021, 117:
104384.
9.
Xiaoyu Hong, Xiaofang Zhong,
Guangsheng Du
, Yingying Hou, Yunting Zhang, Zhirong Zhang, Tao Gong, Ling Zhang*, Xun Sun*. The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency.
Science Advances
, 2020, 6:eaaz4462.
10.
Guangsheng Du,
Xun Sun*. Engineering nanoparticulate vaccines for enhancing antigen cross-presentation.
Current Opinion in Biotechnology
, 2020, 66:113-122.
11.
Guangsheng Du
, Rania M. Hathout, Maha Nasr, M. Reza Nejadnik, Jing Tu, Roman I. Koning, Abraham J. Koster, Bram Slütter, Alexander Kros, Wim Jiskoot, Joke A. Bouwstra*, Juha Mönkäre. Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles.
Journal of Controlled Release
, 2017, 255:109-118.
12.
Anne Marit de Groot
#
,
Guangsheng Du
#
, Juha Mönkäre, Anouk C.M. Platteel, Femke Broere, Joke A. Bouwstra, Alice J.A.M. Sijts*. Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium.
Journal of Controlled Release
, 2017, 266:27-35.
