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I had same issue with Inter font, I wanted to use medium variant but regular was applied no matter what I pick. I could achieved it using gsettings from terminal, adding a comma between font name and size.

gsettings set org.gnome.desktop.interface font-name 'Inter Medium, 11'
Try it, it worked with medium variant but it didn't with light, also note that gnome Tweaks will show up as none font is selected.
                Good to know. I solved it by only installing the fonts that had the weight I wanted, but I think this is a more flexible solution.
– Matthew Layton
                Oct 14, 2019 at 15:58
                One specific roboto medium variant is know to work. The unhinted version in the repo does not. Above solution isnt working for me with SF Pro Display
– Jay Aurabind
                Aug 15, 2020 at 13:33