The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Share The serotype distribution of Streptococcus pneumoniae varies through time. The introduction of pneumococcal conjugate vaccines showed a decreased prevalence of pneumococcal invasive isolates belonging to serotype 14 and an increase of serotypes not therein included. In 1993, the Hospital de Niños of Santa Fe began surveillance of the serotype distribution of invasive S. pneumoniae disease. In the period 2003-2005, 76 isolates were analysed by studying the correlation between serotype and pathology, age and MIC of penicillin. Serotype 14 was the most frequent followed by serotypes 1, 6B, 18C, 7F, 19 F and 5. Serotype 14 showed a statistically significant correlation with MICs of penicillin ranging from 0,5 to 2 mg/l. Although this serotype was more frequently observed in pneumonia than in meningitis, there was not a significant association with any particular pathology. Serotypes 14 and 1, were prevalent among children under and over 2 years old, respectively. Most of these isolates with MICs of penicillin = 2 mg/l, were from patients with pneumonia and not with meningitis. The serotype distribution was similar to that during the period 1993-99, with the exception of serotypes 18C, 4, 12F and 22F which had never been found before. The emergence of these serotypes makes it essential to continue surveillance to determine which conjugated vaccine formulation would be suitable to prevent the most frequent pneumococcal invasive infections. Motlová J. Epidemiol Mikrobiol Imunol. 2005 Feb;54(1):3-10. Epidemiol Mikrobiol Imunol. 2005. PMID: 15807381 Arifeen SE, et al. Clin Infect Dis. 2009 Mar 1;48 Suppl 2:S103-13. doi: 10.1086/596543. Clin Infect Dis. 2009. PMID: 19191605 Saha SK, et al. Clin Infect Dis. 2009 Mar 1;48 Suppl 2:S75-81. doi: 10.1086/596544. Clin Infect Dis. 2009. PMID: 19191622 Dagan R. Clin Microbiol Infect. 2009 Apr;15 Suppl 3:16-20. doi: 10.1111/j.1469-0691.2009.02726.x. Clin Microbiol Infect. 2009. PMID: 19366365 Rodgers GL, et al. Vaccine. 2009 Jun 12;27(29):3802-10. doi: 10.1016/j.vaccine.2009.04.021. Epub 2009 Apr 25. Vaccine. 2009. PMID: 19446378 Bardach A, et al. PLoS One. 2024 Jun 27;19(6):e0304978. doi: 10.1371/journal.pone.0304978. eCollection 2024. PLoS One. 2024. PMID: 38935748 Free PMC article. Gentile A, et al. PLoS One. 2018 Jul 18;13(7):e0199989. doi: 10.1371/journal.pone.0199989. eCollection 2018. PLoS One. 2018. PMID: 30020977 Free PMC article. Zhang L, et al. Vaccine. 2015 Aug 26;33(36):4430-6. doi: 10.1016/j.vaccine.2015.06.077. Epub 2015 Jun 30. Vaccine. 2015. PMID: 26141012 Free PMC article. Review. Castañeda E, et al. BMC Infect Dis. 2012 May 28;12:124. doi: 10.1186/1471-2334-12-124. BMC Infect Dis. 2012. PMID: 22639955 Free PMC article. Review.