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1
School of Medicine, Department of Psychiatry, Koç University, İstanbul, Turkey.
2
Research Center for Translational Medicine, Koç University, İstanbul, Turkey.
3
Child Mind Institute, New York, NY, USA.
4
School of Medicine, Koç University, İstanbul, Turkey.
5
Koç University Hospital, İstanbul, Turkey.
6
Harvard Medical School, Boston, MA, USA.
7
McLean Hospital, Belmont, MA, USA.
1
School of Medicine, Department of Psychiatry, Koç University, İstanbul, Turkey.
2
Research Center for Translational Medicine, Koç University, İstanbul, Turkey.
3
Child Mind Institute, New York, NY, USA.
4
School of Medicine, Koç University, İstanbul, Turkey.
5
Koç University Hospital, İstanbul, Turkey.
6
Harvard Medical School, Boston, MA, USA.
7
McLean Hospital, Belmont, MA, USA.
Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta-analysis and meta-regression study about the comorbidity and covariates of AD and PBD.
Thirty-seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive-compulsive disorder (OCD) was 16.7%. Childhood-onset studies reported higher GAD and SAD comorbidity, while adolescent-onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders' comorbidity with PBD differently.
Nabavi B, et al.
EBioMedicine. 2015 Sep 8;2(10):1405-19. doi: 10.1016/j.ebiom.2015.09.006. eCollection 2015 Oct.
EBioMedicine. 2015.
PMID:
26629535
Free PMC article.
Kim SW, et al.
J Affect Disord. 2014 Sep;166:243-8. doi: 10.1016/j.jad.2014.05.017. Epub 2014 May 23.
J Affect Disord. 2014.
PMID:
25012437
Yapici Eser H, et al.
Front Psychiatry. 2018 Jun 27;9:229. doi: 10.3389/fpsyt.2018.00229. eCollection 2018.
Front Psychiatry. 2018.
PMID:
29997527
Free PMC article.
Fahrendorff AM, et al.
Acta Psychiatr Scand. 2023 Aug;148(2):110-132. doi: 10.1111/acps.13548. Epub 2023 Mar 28.
Acta Psychiatr Scand. 2023.
PMID:
36941106
Review.
Friborg O, et al.
J Affect Disord. 2013 Feb 20;145(2):143-55. doi: 10.1016/j.jad.2012.07.004. Epub 2012 Sep 21.
J Affect Disord. 2013.
PMID:
22999891
Review.
Tesfaye M, et al.
medRxiv [Preprint]. 2023 Sep 2:2023.09.01.23294920. doi: 10.1101/2023.09.01.23294920.
medRxiv. 2023.
PMID:
37693403
Free PMC article.
Preprint.
Hours C.
Child Psychiatry Hum Dev. 2023 Apr 25. doi: 10.1007/s10578-023-01534-9. Online ahead of print.
Child Psychiatry Hum Dev. 2023.
PMID:
37097506
Sesso G, et al.
Curr Neuropharmacol. 2023;21(4):911-934. doi: 10.2174/1570159X20666220706104117.
Curr Neuropharmacol. 2023.
PMID:
35794777
Free PMC article.
Review.
Liu L, et al.
Front Psychiatry. 2022 May 27;13:882616. doi: 10.3389/fpsyt.2022.882616. eCollection 2022.
Front Psychiatry. 2022.
PMID:
35711585
Free PMC article.
Review.
Stanislaus S, et al.
Evid Based Ment Health. 2021 Nov;24(4):137-144. doi: 10.1136/ebmental-2021-300259. Epub 2021 Jun 3.
Evid Based Ment Health. 2021.
PMID:
34083204
Free PMC article.
Clinical Trial.
