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</noscript><div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas=""><div class="page page--node-bundle--scientific-output page--node--efsajournal-pub-2383"><div id="eu-banner" class="bg-light position-relative ps-1" role="banner" aria-labelledby="official-eu-website"> <img src="/themes/custom/efsa_theme/resources/images/eu_flag.svg" width="24" height="16" class="ms-md-3" alt="EU flag"/><div class="eu-banner-content d-inline-block py-1 ps-1 d-md-none">An official EU website</div><div class="eu-banner-content d-inline-block py-1 ps-2 d-none d-md-inline-block" id="official-eu-website">An official website of the European Union</div> <button class="bg-light border-0 d-inline-block ms-1 ms-md-3 py-1 text-primary align-baseline btn btn-link popover" type="button" data-bs-toggle="popover" data-bs-html="true" data-bs-trigger="click" data-bs-placement="bottom"> How do you know? </button> <span class="d-none position-absolute popover-content-wrapper">All official European Union website addresses are in the &lt;b&gt;europa.eu&lt;/b&gt; domain</span></div> <nav class="text-white d-none d-lg-block" id="efsa-top-bar-nav" aria-label="Other EFSA sites"><div id="efsa-top-bar" class="d-flex text-white bg-primary"><ul><li> <span class="text-decoration-none text-white">Other sites</span><ul><li class="active Selected"> <span class="text-decoration-none">EFSA</span></li><li> <a href="https://open.efsa.europa.eu" class="text-decoration-none text-white">Open EFSA</a></li><li> <a href="https://efsa.onlinelibrary.wiley.com/journal/18314732" class="text-decoration-none text-white">EFSA Journal</a></li><li> <a href="https://connect.efsa.europa.eu/RM/s" class="text-decoration-none text-white">Connect</a></li></ul></li></ul></div> </nav> <header><div class="container header pt-lg-3 pb-lg-3"><div class="row align-items-center"><div class="col-8 col-sm-6 efsa-branding-block"><div id="block-efsa-theme-sitebranding"> <a href="/en" rel="home" class="site-logo d-lg-flex flex-wrap align-items-end text-decoration-none"> <img class="me-xl-3" src="/themes/custom/efsa_theme/logo.svg?efsa_token=kaqYufmYTFitLUjBMDd6pSjpf-qRknYXxzm19xKWAuE" alt="Home - European Food Safety Authority" id="block-efsa-theme-sitebranding" width="300" height="79"/> <span class="site-name d-inline-block text-uppercase mt-2 lh-sm">European Food Safety Authority</span> </a></div></div><div class="col-4 col-sm-6 col-lg-auto efsa-utilities-block"><div class="d-flex align-items-center justify-content-sm-end"> <section class="language-switcher"><div class="language-switcher-language-url" id="block-efsa-theme-languageswitcherinterfacetext" role="navigation" aria-label="Language switcher"><div class="language-block"> <a href="#" data-bs-toggle="modal" data-bs-target="#modal-555" class="header__language-switcher-link d-flex flex-column flex-xxl-row me-xxl-4 justify-content-center align-items-center text-decoration-none"> <span class="code fw-bold ms-2 me-3 mt-3 mt-xxl-1 d-inline-block text-white position-relative text-uppercase text-center bg-primary" aria-hidden="true">en</span> <span class="text text-center text-xxl-start mt-2 mt-xxl-0 d-inline-block text-primary">English</span> </a><div class="language-modal modal fade" data-bs-backdrop="static" id="modal-555" tabindex="-1" aria-labelledby="modal-555Label" aria-hidden="true"><div class="modal-dialog modal-sm"><div class="modal-content"><div class="modal-header"><h4 class="modal-title" id="modal-555Label">Select your language</h4> <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"/></div><div class="modal-body"><div><p>Many pages on this website have been translated using automatic translation. 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id="block-efsa-theme-breadcrumbs"> <nav aria-label="breadcrumb"><ol class="breadcrumb rounded-0 mt-2 mb-3 p-2"><li class="breadcrumb-item d-md-inline-block d-inline-block"><a href="/en">Home</a></li><li class="breadcrumb-item d-none d-md-inline-block" aria-current="page"><a href="/en/publications">Publications</a></li></ol></nav></div><div data-drupal-messages-fallback="" class="hidden"/></div> </header><div id="main-content" tabindex="-1"/><div class="page__content"><div class="container"><div id="block-efsa-theme-content"> <article class="node scientific-output node--full scientific-output--full full"><div class="node__content-wrapper"><div class="layout layout--efsa-grid-1-col row"><div class="layout__region layout__region--first col"><div/></div></div><div class="content layout layout--efsa-sidebar row"><div class="layout__region layout__region--main col-lg-12 order-lg-1"><div><h1 class="display-6 inpage-nav-label pb-3 pt-1 mb-2 text-break fw-bold" id="efsa-page-title"> <span> Scientific Opinion on the substantiation of a health claim related to “Appl’In® polyphenolic apple extract powder (Malus domestica)” and reduction of post-prandial glycaemic responses pursuant to Article 13(5) of Regulation (EC) No 1924/2006 </span></h1></div><div><div class="node scientific-output scientific-output--metadata node--metadata d-xl-flex justify-content-between mb-4 mb-lg-5"><div class="node--metadata--content align-self-center"><div class="layout layout--efsa-grid-3-cols row g-0"><div class="col-xl-auto col-lg-auto col-md-12 col-sm-12 col-12 layout__region layout__region--first col"><div><div class="field-published-date scientific-output__field-published-date d-flex"><div class="field__label fw-bold"> Published<span class="me-1">:</span></div><div class="field__item"><time datetime="2011-10-05T12:00:00Z" class="small">5 October 2011</time></div></div></div></div><div class="col-xl-auto col-lg-auto col-md-12 col-sm-12 col-12 layout__region layout__region--second col"><div><div class="field-approved-date scientific-output__field-approved-date d-flex"><div class="field__label fw-bold"> Adopted<span class="me-1">:</span></div><div class="field__item"><time datetime="2011-09-14T12:00:00Z" class="small">14 September 2011</time></div></div></div></div></div></div><div id="oe-webtools-metadata-wrapper"><div id="block-efsa-theme-socialsharingblock"><div class="efsa-social-media-share d-flex align-items-top"> <span class="me-2 mt-1">Share:</span><div class="social-media-sharing"><ul class="social-share-networks"><li> <a target="_blank" rel="noopener noreferrer" class="twitter share" href="https://twitter.com/intent/tweet?url=https%3A//www.efsa.europa.eu/en/efsajournal/pub/2383&amp;text=Appl%E2%80%99In%C2%AE%20and%20reduction%20of%20post-prandial%20glycaemic%20responses%20%7C%20EFSA" title="Share via Twitter"> Share via Twitter </a></li><li> <a target="_blank" rel="noopener noreferrer" class="facebook-share share" 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Library</div><div class="mt-4"><div class="layout layout--efsa-grid-1-col row"><div class="layout__region layout__region--first col"><div><div class="field-digital-object-identifier scientific-output__field-digital-object-identifier"><div class="fw-bold"> Full article<span class="me-1">:</span></div><div class="field__item d-flex flex-wrap align-items-center"><div> <a target="blank" href="https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2011.2383">Read online at EFSA Journal<svg class="ms-2 file--pdf ms-2-5 bi icon--s"><use xlink:href="/themes/custom/efsa_theme/resources/images/links_icons/efsa-icons-sprite.svg#external"/></svg></a></div><div> <a target="blank" href="https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2011.2383">Full article (online viewer)<svg class="ms-1 file--pdf ms-2-5 bi icon--s"><use xlink:href="/themes/custom/efsa_theme/resources/images/links_icons/efsa-icons-sprite.svg#file-earmark-pdf"/></svg></a></div></div></div></div></div></div></div></div></div><div class="mb-5"><h2 class="inpage-nav-label">Meta data</h2> <article class="node scientific-output node--so-metadata scientific-output--so-metadata so-metadata"><div class="node__content-wrapper"><div class="layout layout--onecol"><div class="layout__region layout__region--content"><div class="mb-2 border-bottom"><div class="text-break d-md-flex field-digital-object-identifier scientific-output__field-digital-object-identifier"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> DOI</div><div class="field__item"><a href="https://doi.org/10.2903/j.efsa.2011.2383">https://doi.org/10.2903/j.efsa.2011.2383</a></div></div></div><div class="mb-2 border-bottom"><div class="text-break d-md-flex field-keywords scientific-output__field-keywords"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> Keywords</div><div class="field__item">Apple, polyphenolic extract, phloridzin, post-prandial glycaemic response, health claim</div></div></div><div class="mb-2 border-bottom"><div class="text-break d-md-flex field-so-requestor scientific-output__field-so-requestor"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> On request from</div><div class="field__item">Competent Authority of France</div></div></div><div class="mb-2 border-bottom"><div class="text-break d-md-flex field-so-roq-references scientific-output__field-so-roq-references"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> Question Number</div><div class="field__items"><div class="field__item">EFSA-Q-2011-00190</div></div></div></div><div class="mb-2 border-bottom"><div class="text-break d-md-flex field-panels scientific-output__field-panels"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> Panels</div><div class="field__items"><div class="field__item"><a href="/en/science/scientific-committee-and-panels/nda" hreflang="en">Nutrition, Novel Foods and Food Allergens</a></div></div></div></div><div class="mb-2 border-bottom"><div class="text-break d-md-flex field-so-panel-members scientific-output__field-so-panel-members"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> Panel members at the time of adoption</div><div class="field__item">Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser-Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren and Hans Verhagen</div></div></div><div><div class="text-break d-md-flex field-correspondence scientific-output__field-correspondence"><div class="mb-2 text-muted text-uppercase fw-normal text-wrap field__label"> Contact</div><div class="field__items"><div class="field__item"><a href="mailto:nda@efsa.europa.eu">nda@efsa.europa.eu</a></div></div></div></div></div></div></div> </article></div><div><div class="field-so-abstract scientific-output__field-so-abstract"><h2 class="inpage-nav-label" id="abstract"> Abstract</h2><div class="field__item"><p>Following an application from Diana Naturals pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to “Appl’In<sup>®</sup> polyphenolic apple extract powder (<em>Malus domestica</em>)” and reduction of post-prandial glycaemic responses. The food constituent, Appl’In<sup>®</sup> polyphenolic apple extract powder (<em>Malus domestica </em>Borkh.) containing at least 5 % phloridzin, is considered to be sufficiently characterised in relation to the claimed effect. The Panel considers that reduction of post prandial glycaemic responses (as long as post-prandial insulinaemic responses are not disproportionally increased) may be a beneficial physiological effect. The applicant provided one published and two unpublished human studies, three animal studies and two <em>in vitro</em> studies as pertinent to the claim. The Panel notes that the food used in one human study did not comply with the specifications of the food which is the subject of the claim and considers that no conclusion can be drawn from this study for the scientific substantiation of the claim. In two other human studies, post-prandial blood glucose concentrations were measured but not insulin responses. The Panel considers that no conclusions can be drawn from these studies for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of Appl’In<sup>®</sup> and reduction of post-prandial glycaemic responses.</p></div></div></div><div class="mt-3 mb-5"><div class="field-so-copyright scientific-output__field-so-copyright"><div class="small text-muted">© European Food Safety Authority, 2011</div></div></div><div><div class="field-topics scientific-output__field-topics"><h2 class="inpage-nav-label" id="related-topic"> Related topic</h2><div class="field__items d-inline-flex flex-wrap"> <a class="me-3 mb-3 badge efsa-badge py-2 px-3 mb-2 rounded-pill text-corporate-blue bg-general-blue-light" data-topic-name="nutrition" data-topic-level="1" aria-describedby="related-topic" href="/en/topics/topic/nutrition"> Nutrition </a></div></div></div></div><div class="layout__region layout__region--inpage-nav col-lg-3 mb-5 d-none order-lg-2 sticky-bottom"><div class="inpage-nav-container sticky-top mt-4 mt-lg-0 ps-lg-4 pe-lg-3 pb-lg-4 d-none d-lg-block"> <nav aria-label="Page contents" data-scope=".page__content" data-container=".layout__region--inpage-nav" data-heading-selector="h1.inpage-nav-label, h2.inpage-nav-label" class="inpage-nav bcl-inpage-navigation position-sticky" id="bcl-inpage-navigation"><h2 class="h5 efsa-page-title-toc-heading mt-0 mb-3 ps-md-2 py-2 mb-0 bcl-heading"><a class="nav-link standalone" href="#efsa-page-title">Contents</a></h2><ul class="nav flex-column"/></nav></div><div class="d-block d-lg-none mb-2"><div class="offcanvas rounded-top h-auto offcanvas-lg offcanvas-bottom" id="bcl-offcanvas" data-bs-scroll="true" tabindex="-1"><div class="offcanvas-header"><button class="btn-close text-reset" data-bs-dismiss="offcanvas" data-bs-target="#bcl-offcanvas" aria-label="" type="button"/></div><div class="offcanvas-body"><nav aria-label="Page contents" data-scope=".page__content" data-container=".layout__region--inpage-nav" data-heading-selector="h1.inpage-nav-label, h2.inpage-nav-label" class="inpage-nav bcl-inpage-navigation position-sticky" id="bcl-inpage-navigation--2"><h2 class="h5 efsa-page-title-toc-heading mt-0 mb-3 ps-md-2 py-2 mb-0 bcl-heading"><a class="nav-link standalone" href="#efsa-page-title">Contents</a></h2><ul class="nav flex-column"/></nav></div></div> <button class="offcanvas-toggler col-12 btn btn-primary btn-md" data-bs-toggle="offcanvas" data-bs-target="#bcl-offcanvas" aria-controls="bcl-offcanvas" type="button"><svg class="me-2-5 bi icon--fluid"><use xlink:href="/themes/custom/efsa_theme/resources/images/links_icons/efsa-icons-sprite.svg?efsa_token=kaqYufmYTFitLUjBMDd6pSjpf-qRknYXxzm19xKWAuE#filter"/></svg>Page contents</button></div></div></div> </div></article></div></div> <footer class="page__footer"><div class="container"><div class="d-flex justify-content-md-between align-items-md-center"><div id="block-efsacustomuserfeedbackformblock"><form class="efsa-core-user-feedback-form" data-drupal-selector="efsa-core-user-feedback-form" action="https://europa.eu/webtools/rest/wform/submissions/register" method="post" id="efsa-core-user-feedback-form" accept-charset="UTF-8"><fieldset data-drupal-selector="edit-expectations" id="edit-expectations--wrapper" class="fieldgroup form-composite js-form-item form-item js-form-wrapper mb-3"><legend class="col-form-label"> <span class="fieldset-legend">Did this page meet your expectations ?</span></legend><div class="fieldset-wrapper col-sm-10"><div id="edit-expectations" class="form-radios"><div class="js-form-item form-item js-form-type-radio form-item-expectations js-form-item-expectations form-check"> <input class="visually-hidden form-radio form-check-input" data-drupal-selector="edit-expectations-yes" type="radio" id="edit-expectations-yes" name="expectations" value="yes"/> <label class="form-check-label option form-label" for="edit-expectations-yes">Yes</label></div><div class="js-form-item form-item js-form-type-radio form-item-expectations js-form-item-expectations form-check"> <input class="visually-hidden form-radio form-check-input" data-drupal-selector="edit-expectations-no" type="radio" id="edit-expectations-no" name="expectations" value="no"/> <label class="form-check-label option form-label" for="edit-expectations-no">No</label></div></div></div></fieldset><fieldset class="mb-3 fieldgroup form-composite js-form-item form-item js-form-wrapper" data-drupal-selector="edit-yes-feedback" id="edit-yes-feedback--wrapper" data-drupal-states="{&quot;visible&quot;:{&quot;:input[name=\u0022expectations\u0022]&quot;:{&quot;value&quot;:&quot;yes&quot;}}}"><legend class="col-form-label"> <span class="fieldset-legend">Thank you! 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