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1
From Mayo Clinic School of Medicine (K.M.B.).
2
the Department of Radiology (W.B., L.J.E., D.F.K., R.J.M., C.M.C.), Mayo Clinic, Rochester, Minnesota.
3
the Department of Radiology (W.B., L.J.E., D.F.K., R.J.M., C.M.C.), Mayo Clinic, Rochester, Minnesota. [email protected].
1
From Mayo Clinic School of Medicine (K.M.B.).
2
the Department of Radiology (W.B., L.J.E., D.F.K., R.J.M., C.M.C.), Mayo Clinic, Rochester, Minnesota.
3
the Department of Radiology (W.B., L.J.E., D.F.K., R.J.M., C.M.C.), Mayo Clinic, Rochester, Minnesota. [email protected].
The dentate nucleus is a cerebellar structure involved in voluntary motor function and cognition. There are relatively few entities that affect the dentate, and the clinical features of these conditions are often complex and nonspecific. Because these entities are rarely encountered, the formulation of a differential diagnosis can be difficult. Many of the conditions are reversible or treatable with early intervention. Therefore, it is important to recognize classic clinical presentations and their associated characteristic imaging findings. We provide a summary of entities that affect the dentate nucleus and a diagnostic workflow for approaching dentate nucleus imaging abnormalities.
Hypertensive hemorrhage. A 55-year-old man who presented with a thalamic hemorrhage. Three selected images from 3D susceptibility-weighted imaging demonstrate microhemorrhages and hemosiderin deposition within the dentate nuclei (
white arrows
), brain stem, thalamus, and basal ganglia. The sentinel bleed is shown with
black arrows
. This distribution is characteristic of hypertensive microhemorrhages. The patient was being treated with multiple medications to control his hypertension, which remained elevated even during his hospitalization.
Gadolinium deposition. A 13-year-old boy was diagnosed with a pilocytic astrocytoma and treated with chemotherapy, but no radiation.
A
, the first available pregadolinium T1WI without any abnormality in the dentate.
B
, A follow-up examination performed 10 years later now demonstrates T1 hyperintensity on TIWI within the dentate nuclei (
arrows
). The patient had undergone 37 gadolinium-enhanced examinations at this time point.
Fahr disease.
A–D
, CT and T2* gradient recalled-echo images from a 49-year-old patient with Fahr disease demonstrate dense calcification of the dentate nuclei and basal ganglia.
E
and
F
, Dense calcification within the dentate nuclei and basal ganglia is also well-demonstrated on susceptibility-weighted imaging, in this case from a 68-year-old affected woman.
Leigh disease. An 11-year-old girl diagnosed at 2 years of age with Leigh disease. Marked T2 hyperintensity on FLAIR within the dentate nuclei (
A
and
B
) and basal ganglia (
C
). MR spectroscopy with voxel sampling of the basal ganglia (
D
) demonstrates a prominent lactate doublet (at 1.3 ppm) and elevated choline (at 3.2 ppm).
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